FRACTALKINE DEPRESSES CARDIOMYOCYTE CONTRACTILITY.

Fractalkine depresses cardiomyocyte contractility.

Our laboratory reported that male mice with cardiomyocyte-selective knockout of the prostaglandin E2 EP4 receptor sub-type (EP4 KO) exhibit reduced cardiac read more function.Gene array on left ventricles (LV) showed increased fractalkine, a chemokine implicated in heart failure.We therefore hypothesized that fractalkine is regulated by PGE2 and co

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